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The cytotoxic plant protein, beta-puothionin, forms ion channels in lipid membranes

Hughes, P; Dennis, Elizabeth; Whitecross, Malcolm; Llewellyn, Danny; Gage, Peter


Thionins are small cysteine-containing, amphipathic plant proteins found in seeds and vegetative tissues of a number of plant genera. Many of them have been shown to be toxic to microorganisms such as fungi, yeast, and bacteria and also to mammalian cells. It has been suggested that thionins are present in seeds to protect them, and the germinating seedling, from attack by phytopathogenic microorganisms, but the mechanism by which they kill cells remains unclear. Using electrophysiological...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.275.2.823


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