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Paraoxonase polymorphisms, pesticide exposure and Parkinsons disease in a Caucasian population

Taylor, Matthew; Le Couteur, D; Mellick, G; Board, Philip


Parkinson's disease (PD) has been associated with exposure to pesticides and oxidative injury. The involvement of paraoxonase in both pesticide metabolism and lipid peroxidation suggests that it may play a role in the pathogenesis of PD. We examined the frequency of polymorphic alleles of the PON1 and PON2 genes in a sample of caucasian subjects with PD. The frequency distribution of these genotypes did not differ significantly between patients and controls, including those who had reported...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Journal of Neural Transmission
DOI: 10.1007/s007020070046


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