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Resistance of photoreceptors in the C57BL/6-c2J, C57BL/6J, and BALB/cJ mouse strains to oxygen stress: Evidence of an oxygen phenotype

Walsh, Natalie; Bravo-Nuevo, A; Stone, Jonathan

Description

Purpose. To assess the vulnerability of retinal photoreceptors in the BALB/cJ, C57BL/6J, and C57BL/6-c2J (c2J) mouse strains to hypoxic and hyperoxic stress. Methods. Mice were raised in dim cyclic light. Pups aged postnatal day 7 (P7) were exposed to hypoxia (11-12% oxygen) for periods up to 23 days. Adult mice were exposed to either hypoxia (12% oxygen) or to hyperoxia (75% oxygen) for up to 2 weeks. Using the TUNEL (terminal dUTP-mediated nick end labeling) technique retinas were examined...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/88712
Source: Current Eye Research
DOI: 10.1080/02713680490522416

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