Subtype AE HIV-1 DNA and recombinant Fowlpoxvirus vaccines encoding five shared HIV-1 genes: safety and T cell immunogenicity in macaques
De Rose, Robert; Chea, Socheata; Dale, C Jane; Reece, Jeanette; Fernandez, Caroline S; Wilson, Kim M; Thomson, Scott; Ramshaw, Ian; Coupar, Barbara E H; Boyle, David B; Sullivan, Mark T; Kent, Stephen J
To induce broad T cell immunity to HIV-1, we evaluated the safety, immunogenicity and dose-response relationship of DNA and recombinant Fowlpoxvirus (rFPV) vaccines encoding five shared HIV subtype AE genes (Gag, Pol, Env, Tat, Rev) in pigtail macaques. The DNA (three doses of either 1 mg or 4.5 mg) and rFPV (a single boost of either 5 × 107 or 2 × 108 plaque forming units) vaccines were administered intramuscularly without adjuvants. Broadly reactive HIV-specific T cell immunity was stimulated...[Show more]
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