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Surface plasmon resonance to determine apparent stability constants for the binding of cyclodextrins to small immobilized guests

Brown, Susan Elizabeth; Easton, Christopher; Kelly, James


Surface plasmon resonance (SPR) has been used to determine apparent stability constants for the non-covalent interactions of cyclodextrin (CD) hosts with small organic guests. This technique allows detection of the molecular interactions by monitoring changes in refractive index at gold surfaces on which the guests are immobilized. The magnitude of an SPR response is proportional to the mass change at a surface, and thus the technique has most commonly been used in the past to study large...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Inclusion Phenomena and Macrocyclic Chemistry
DOI: 10.1023/A:1026311003881


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