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Recombinant modular transporters for cell-specific nuclear delivery of locally acting drugs enhance photosensitizer activity

Rosenkranz, Andrey; Lunin, Vladimir; Gulak, Pavel; Sergienko, Olga; Schumiantseva, Maria; Voronina, Olga; Gilyazova, Dinara; John, Anna; Kofner, Anna; Mironov, Andrey; Jans, David A; Sobolev, Alexander S


The search for new pharmaceuticals that are specific for diseased rather than normal cells in the case of cancer and viral disease has raised interest in locally acting drugs that act over short distances within the cell and for which different cell compartments have distinct sensitivities. Thus, photosensitizers (PSs) used in anti-cancer therapy should ideally be transported to the most sensitive subcellular compartments in order for their action to be most pronounced. Here we describe the...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: FASEB Journal


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