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The random-coil C fragment of the dihydropyridine receptor II-III loop can activate or inhibit native skeletal ryanodine receptors

Haarmann, Claudia; Green, Daniel; Casarotto, Marco; Laver, Derek Rowland; Dulhunty, Angela


The actions of peptide C, corresponding to 724Glu-Pro760 of the II-III loop of the skeletal dihydropyridine receptor, on ryanodine receptor (RyR) channels incorporated into lipid bilayers with the native sarcoplasmic reticulum membrane show that the peptide is a high-affinity activator of native skeletal RyRs at cytoplasmic concentrations of 100 nM-10 μM. In addition, we found that peptide C inhibits RyRs in a voltage-independent manner when added for longer times or at higher concentrations...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Biochemistry
DOI: 10.1042/BJ20021763


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