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Conductance of GABAA channels activated by pentobarbitone in hippocampal neurons from newborn rats

Eghbali, Mansoureh; Birnir, Bryndis; Gage, Peter


Neurons were obtained from the CA1 region of the hippocampus of newborn rats and maintained in culture. Channels were activated by pentobarbitone in cell-attached, inside-out or outside-out patches, normally by applying pentobarbitone in flowing bath solution. Currents were outwardly rectifying and blocked by bicuculline, properties of GABAA channels in these cells. Maximum channel conductance increased as pentobarbitone concentration was increased to 500 μM but conductance then decreased as...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Physiology
DOI: 10.1113/jphysiol.2003.047415


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