Polymorphisms in the IL18 gene are associated with specific sensitization to common allergens and allergic rhinitis
Background: Atopy has been linked to chromosome 11q22, a region that harbors the IL18 gene. IL-18 enhances IL-4/IL-13 production and induces IgE production that is directly associated with the pathogenesis of atopic disorders. Objective: We sought to investigate whether genetic abnormalities in the regulatory regions of the IL18 gene predispose, in part, to susceptibility to atopy. Methods: Among a white population of 105 families, the oldest child was examined with regard to atopic phenotypes...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Allergy and Clinical Immunology|
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