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Polymorphisms in the IL18 gene are associated with specific sensitization to common allergens and allergic rhinitis

Kruse, Susanne; Kuehr, Joachim; Moseler, Michael; Kopp, Matthias; Kurz, Thorsten; Deichmann, Klaus; Foster, Paul S; Mattes, Joerg

Description

Background: Atopy has been linked to chromosome 11q22, a region that harbors the IL18 gene. IL-18 enhances IL-4/IL-13 production and induces IgE production that is directly associated with the pathogenesis of atopic disorders. Objective: We sought to investigate whether genetic abnormalities in the regulatory regions of the IL18 gene predispose, in part, to susceptibility to atopy. Methods: Among a white population of 105 families, the oldest child was examined with regard to atopic phenotypes...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
URI: http://hdl.handle.net/1885/88529
Source: Journal of Allergy and Clinical Immunology
DOI: 10.1067/mai.2003.43

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