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Chemokines in asthma: Cooperative interaction between chemokines and IL-13

Zimmermann, Nives; Hershey, Gurjit; Foster, Paul S; Rothenberg, Marc E

Description

The asthmatic response is characterized by elevated production of IgE, cytokines, chemokines, mucus hypersecretion, airway obstruction, eosinophilia, and enhanced airway hyperreactivity to spasmogens. Clinical and experimental investigations have demonstrated a strong correlation between the presence of CD4+ TH2 cells, eosinophils, and disease severity, suggesting an integral role for these cells in the pathophysiology of asthma. TH2 cells are thought to induce asthma through the secretion of...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
URI: http://hdl.handle.net/1885/88528
Source: Journal of Allergy and Clinical Immunology
DOI: 10.1067/mai.2003.139

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