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Immunotherapy of Cytotoxic T Cell-resistant Tumors by T Helper 2 Cells: An Exotaxin and STAT6-dependent Process

Mattes, Joerg; Hulett, Mark; Xie, Wei; Hogan, Simon; Rothenberg, Marc E; Foster, Paul S; Parish, Christopher


Currently most attempts at cancer immunotherapy involve the generation of CD8+ cytotoxic T lymphocytes (CTLs) against tumor-associated antigens. Many tumors, however, have been immunoselected to evade recognition by CTLs and thus alternative approaches to cancer immunotherapy are urgently needed. Here we demonstrate that CD4+ T cells that recognize a secreted tumor-specific antigen and exhibit a cytokine secretion profile characteristic of Th2 cells, are capable of clearing established lung and...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.20021683


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