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Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity

Yang, Ming; Hogan, Simon; Mahalingam, Surendran; Pope, Samuel; Zimmermann, Nives; Fulkerson, Patricia; Dent, Lindsay; Young, Ian; Matthaei, Klaus; Rothenberg, Marc E; Foster, Paul S

Description

Background: Eotaxin-2 is a member of the eotaxin subfamily of CC chemokines that display eosinophil-specific, chemotactic properties and has been associated with allergic disorders. However, the contribution of eotaxin-2 to the development of defined pathogenic features of allergic disease remains to be defined. Objective: We sought to determine whether eotaxin-2 was a cofactor with IL-5 for the regulation of pulmonary eosinophilia and to identify the combined role of these molecules in the...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
URI: http://hdl.handle.net/1885/88514
Source: Journal of Allergy and Clinical Immunology
DOI: 10.1016/j.jaci.2003.08.010

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