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Inefficient Signalase Cleavage Promotes Efficient Nucleocapsid Incorporation into Budding Flavivirus Membranes

Lobigs, Mario; Lee, Eva


The mechanism for efficient nucleocapsid (NC) uptake into flavivirus particles which form by budding through the membranes of the endoplasmic reticulum (ER) was investigated by using Murray Valley encephalitis virus as a model. Budding of flavivirus membranes is driven by the viral transmembrane proteins prM and E independently of NC interaction. We show that control of signalase cleavage of the multimembrane-spanning flavivirus polyprotein by the catalytic function of the viral protease is...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of Virology
DOI: 10.1128/JVI.78.1.178-186.2004


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