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NMR Structure of the Netrin-like Domain (NTR) of Human Type I Procollagen C-Proteinase Enhancer Defines Structural Consensus of NTR Domains and Assesses Potential Proteinase Inhibitory Activity and Ligand Binding

Liepinsh, Edvards; Banyai, Laszlo; Pintacuda, Guido; Trexler, Maria; Patthy, Laszlo; Otting, Gottfried


Procollagen C-proteinase enhancer (PCOLCE) proteins are extracellular matrix proteins that enhance the activities of procollagen C-proteinases by binding to the C-propeptide of procollagen I. PCOLCE proteins are built of three structural modules, consisting of two CUB domains followed by a C-terminal netrin-like (NTR) domain. While the enhancement of proteinase activity can be ascribed solely to the CUB domains, sequence homology of the NTR domain with tissue inhibitors of metalloproteinases...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M302734200


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