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Intestinal exposure to a parasite antigen in utero depresses cellular and cytokine responses of the mucosal immune system

Paalangara, R; McClure, Susan J; McCullagh, Peter


The response of the mucosal immune system of 4-6-week old lambs to viable Trichostrongylus colubriformis larvae was compared in two groups of animals, one exposed to T. colubriformis antigen and the other to saline while in utero. Exposure to larval antigen two-thirds of the way through gestation resulted in significant reduction in the frequency of jejunal goblet cells and of ileal eosinophils, CD1b+ antigen-presenting cells and CD4+, CD5+ and CD8+ cells. However, it resulted in a significant...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Veterinary Immunology and Immunopathology
DOI: 10.1016/S0165-2427(03)00050-3


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