Skip navigation
Skip navigation

Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling

Rui, Lixin; Garcia De Vinuesa, Maria Carola; Blasioli, Julie; Goodnow, Christopher


CpG sequences in self-DNA are an important potential trigger for autoantibody secretion in systemic lupus and other systemic autoimmune disorders. It is not known how this ubiquitous threat may be controlled by active mechanisms for maintaining self tolerance. Here we show that two distinct mechanisms oppose autoantibody secretion induced by CpG DNA in anergic B cells that are constantly binding self-antigen. Uncoupling of the antigen receptor (BCR) from a calcineurin-dependent pathway prevents...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Nature Immunology
DOI: 10.1038/ni924


There are no files associated with this item.

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator