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Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling

Rui, Lixin; Garcia De Vinuesa, Maria Carola; Blasioli, Julie; Goodnow, Christopher

Description

CpG sequences in self-DNA are an important potential trigger for autoantibody secretion in systemic lupus and other systemic autoimmune disorders. It is not known how this ubiquitous threat may be controlled by active mechanisms for maintaining self tolerance. Here we show that two distinct mechanisms oppose autoantibody secretion induced by CpG DNA in anergic B cells that are constantly binding self-antigen. Uncoupling of the antigen receptor (BCR) from a calcineurin-dependent pathway prevents...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
URI: http://hdl.handle.net/1885/88341
Source: Nature Immunology
DOI: 10.1038/ni924

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