Macrophage migration inhibitory factor exhibits a pronounced circadian rhythm relevant to its role as a glucocorticoid counter-regulator
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Petrovsky, Nikolai; Socha, L; Silva, Diego; Grossman, Arthur Robert; Metz, Christine; Bucala, Richard
Description
In humans, maximal expression of T helper 1 cytokines coincide with the nocturnal nadir of plasma cortisol, whereas T helper 2 cytokine responses are dominant during day-time. The pro-inflammatory cytokine, macrophage migration inhibitory factor counter-regulates glucocorticoid-mediated immune suppression. To determine the relationship between cortisol and macrophage migration inhibitory factor, healthy volunteers had blood drawn hourly for 24 h for measurement of plasma cortisol and basal- and...[Show more]
dc.contributor.author | Petrovsky, Nikolai | |
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dc.contributor.author | Socha, L | |
dc.contributor.author | Silva, Diego | |
dc.contributor.author | Grossman, Arthur Robert | |
dc.contributor.author | Metz, Christine | |
dc.contributor.author | Bucala, Richard | |
dc.date.accessioned | 2015-12-13T23:13:53Z | |
dc.identifier.issn | 0818-9641 | |
dc.identifier.uri | http://hdl.handle.net/1885/88340 | |
dc.description.abstract | In humans, maximal expression of T helper 1 cytokines coincide with the nocturnal nadir of plasma cortisol, whereas T helper 2 cytokine responses are dominant during day-time. The pro-inflammatory cytokine, macrophage migration inhibitory factor counter-regulates glucocorticoid-mediated immune suppression. To determine the relationship between cortisol and macrophage migration inhibitory factor, healthy volunteers had blood drawn hourly for 24 h for measurement of plasma cortisol and basal- and stimulated-macrophage migration inhibitory factor. Similar to cortisol, macrophage migration inhibitory factor peaked during the late morning whereas interferon-γ tumour necrosis factor-α, interleukin-1 and interleukin-12 demonstrated a nocturnal peak. After oral cortisone, plasma macrophage migration inhibitory factor rose 2-4-fold, whereas the other cytokines decreased. There was no correlation between cortisol during the insulin tolerance test and plasma macrophage migration inhibitory factor. The late morning peak of macrophage migration inhibitory factor, by antagonizing cortisol-mediated pro-infiammatory cytokine suppression may prolong the duration of early morning inflammation. These observations explain the beneficial role of macrophage migration inhibitory factor neutralization in models of inflammatory arthritis. | |
dc.publisher | Blackwell Publishing Ltd | |
dc.source | Immunology and Cell Biology | |
dc.subject | Keywords: cortisone acetate; cytokine; dexamethasone; gamma interferon; glucocorticoid; hydrocortisone; interleukin 1; interleukin 12; macrophage migration inhibition factor; neutralizing antibody; tumor necrosis factor alpha; adult; arthritis; article; circadian r Circadian; Cortisol; Cytokine; Diurnal; MIF; Neuroendocrine; Th1; Th2 | |
dc.title | Macrophage migration inhibitory factor exhibits a pronounced circadian rhythm relevant to its role as a glucocorticoid counter-regulator | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.description.refereed | Yes | |
local.identifier.citationvolume | 81 | |
dc.date.issued | 2003 | |
local.identifier.absfor | 110704 - Cellular Immunology | |
local.identifier.ariespublication | MigratedxPub18004 | |
local.type.status | Published Version | |
local.contributor.affiliation | Petrovsky, Nikolai, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Socha, L, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Silva, Diego, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Grossman, Arthur Robert, Carnegie Institution of Washington | |
local.contributor.affiliation | Metz, Christine, Feinstein Institute for Medical Research | |
local.contributor.affiliation | Bucala, Richard, Yale University | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.startpage | 137 | |
local.bibliographicCitation.lastpage | 143 | |
local.identifier.doi | 10.1046/j.0818-9641.2002.01148.x | |
dc.date.updated | 2015-12-12T08:36:10Z | |
local.identifier.scopusID | 2-s2.0-0037383502 | |
Collections | ANU Research Publications |
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