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Macrophage migration inhibitory factor exhibits a pronounced circadian rhythm relevant to its role as a glucocorticoid counter-regulator

Petrovsky, Nikolai; Socha, L; Silva, Diego; Grossman, Arthur Robert; Metz, Christine; Bucala, Richard

Description

In humans, maximal expression of T helper 1 cytokines coincide with the nocturnal nadir of plasma cortisol, whereas T helper 2 cytokine responses are dominant during day-time. The pro-inflammatory cytokine, macrophage migration inhibitory factor counter-regulates glucocorticoid-mediated immune suppression. To determine the relationship between cortisol and macrophage migration inhibitory factor, healthy volunteers had blood drawn hourly for 24 h for measurement of plasma cortisol and basal- and...[Show more]

dc.contributor.authorPetrovsky, Nikolai
dc.contributor.authorSocha, L
dc.contributor.authorSilva, Diego
dc.contributor.authorGrossman, Arthur Robert
dc.contributor.authorMetz, Christine
dc.contributor.authorBucala, Richard
dc.date.accessioned2015-12-13T23:13:53Z
dc.identifier.issn0818-9641
dc.identifier.urihttp://hdl.handle.net/1885/88340
dc.description.abstractIn humans, maximal expression of T helper 1 cytokines coincide with the nocturnal nadir of plasma cortisol, whereas T helper 2 cytokine responses are dominant during day-time. The pro-inflammatory cytokine, macrophage migration inhibitory factor counter-regulates glucocorticoid-mediated immune suppression. To determine the relationship between cortisol and macrophage migration inhibitory factor, healthy volunteers had blood drawn hourly for 24 h for measurement of plasma cortisol and basal- and stimulated-macrophage migration inhibitory factor. Similar to cortisol, macrophage migration inhibitory factor peaked during the late morning whereas interferon-γ tumour necrosis factor-α, interleukin-1 and interleukin-12 demonstrated a nocturnal peak. After oral cortisone, plasma macrophage migration inhibitory factor rose 2-4-fold, whereas the other cytokines decreased. There was no correlation between cortisol during the insulin tolerance test and plasma macrophage migration inhibitory factor. The late morning peak of macrophage migration inhibitory factor, by antagonizing cortisol-mediated pro-infiammatory cytokine suppression may prolong the duration of early morning inflammation. These observations explain the beneficial role of macrophage migration inhibitory factor neutralization in models of inflammatory arthritis.
dc.publisherBlackwell Publishing Ltd
dc.sourceImmunology and Cell Biology
dc.subjectKeywords: cortisone acetate; cytokine; dexamethasone; gamma interferon; glucocorticoid; hydrocortisone; interleukin 1; interleukin 12; macrophage migration inhibition factor; neutralizing antibody; tumor necrosis factor alpha; adult; arthritis; article; circadian r Circadian; Cortisol; Cytokine; Diurnal; MIF; Neuroendocrine; Th1; Th2
dc.titleMacrophage migration inhibitory factor exhibits a pronounced circadian rhythm relevant to its role as a glucocorticoid counter-regulator
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume81
dc.date.issued2003
local.identifier.absfor110704 - Cellular Immunology
local.identifier.ariespublicationMigratedxPub18004
local.type.statusPublished Version
local.contributor.affiliationPetrovsky, Nikolai, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSocha, L, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSilva, Diego, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGrossman, Arthur Robert, Carnegie Institution of Washington
local.contributor.affiliationMetz, Christine, Feinstein Institute for Medical Research
local.contributor.affiliationBucala, Richard, Yale University
local.description.embargo2037-12-31
local.bibliographicCitation.startpage137
local.bibliographicCitation.lastpage143
local.identifier.doi10.1046/j.0818-9641.2002.01148.x
dc.date.updated2015-12-12T08:36:10Z
local.identifier.scopusID2-s2.0-0037383502
CollectionsANU Research Publications

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