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MHC class I up-regulation by flaviviruses: Immune interaction with unknown advantage to host or pathogen

Lobigs, Mario; Mullbacher, Arno; Regner, Matthias

Description

In contrast to many other viruses that escape from cytotoxic T cell recognition by down-regulating major histocompatibility complex class I-restricted antigen presentation, flavivirus infection of mammalian cells upregulates cell surface expression of major histocompatibility complex class I molecules. Two putative mechanisms for flavivirus-induced major histocompatibility complex class I up-regulation, one via activation of the transcription factor NF-κB, the second by augmentation of peptide...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
URI: http://hdl.handle.net/1885/88322
Source: Immunology and Cell Biology
DOI: 10.1046/j.1440-1711.2003.01161.x

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