Blockade of vascular smooth muscle cell proliferation and intimal thickening after balloon injury by the sulfated oligosaccharide PI-88
Francis, Doug; McGarry, Mark; Santiago, Fernando; Lowe, Harry C; Brown, K; Bingley, J; Hayward, Ian; Cowden, William; Campbell, Julie H; Campbell, Gordon R; Chesterman, C; Khachigian, Levon M; Parish, Christopher
Percutaneous transluminal coronary angioplasty is a frequently used interventional technique to reopen arteries that have narrowed because of atherosclerosis. Restenosis, or renarrowing of the artery shortly after angioplasty, is a major limitation to the success of the procedure and is due mainly to smooth muscle cell accumulation in the artery wall at the site of balloon injury. In the present study, we demonstrate that the antiangiogenic sulfated oligosaccharide, PI-88, inhibits primary...[Show more]
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