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Development of B cells in the gut-associated lymphoid tissue of mid-gestational fetal lambs

Alitheen, N; McClure, Susan J; McCullagh, Peter


Intestinal mucosal immune system development was investigated in fetal lambs from 61 to 110 days (term, 150 days). Fetal small intestine was examined at 400 mm intervals for the presence of IgM+ cells. The first phase of B cell development was characterised by increase in B cell density throughout the jejunum from 65 days. Increase in density was greatest in the proximal jejunum and declined progressively approaching the ileum. The second phase entailed a decrease in jejunal B cell...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Developmental and Comparative Immunology
DOI: 10.1016/S0145-305X(02)00139-8


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