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Physics of Ion Channels

Kuyucak, Serdar; Bastug, Turgut

Description

We review the basic physics involved in transport of ions across membrane channels in cells. Electrochemical forces that control the diffusion of ions are discussed both from microscopic and macroscopic perspectives. A case is made for use of Brownian dynamics as the minimal phenomenological model that provides a bridge between experiments and more fundamental theoretical approaches. Application of Brownian and molecular dynamics methods to channels with known molecular structures is discussed.

dc.contributor.authorKuyucak, Serdar
dc.contributor.authorBastug, Turgut
dc.date.accessioned2015-12-13T23:11:35Z
dc.date.available2015-12-13T23:11:35Z
dc.identifier.issn0092-0606
dc.identifier.urihttp://hdl.handle.net/1885/87652
dc.description.abstractWe review the basic physics involved in transport of ions across membrane channels in cells. Electrochemical forces that control the diffusion of ions are discussed both from microscopic and macroscopic perspectives. A case is made for use of Brownian dynamics as the minimal phenomenological model that provides a bridge between experiments and more fundamental theoretical approaches. Application of Brownian and molecular dynamics methods to channels with known molecular structures is discussed.
dc.publisherKluwer Academic Publishers
dc.sourceJournal of Biological Physics
dc.subjectKeywords: antibiotic agent; calcium; calcium channel; gramicidin A; ion channel; potassium; potassium channel; sodium ion; binding site; cell membrane permeability; chemical structure; conductance; conference paper; crystal structure; electrochemistry; ion transpor Brownian dynamics; Continuum theories; Ion channels; Molecular dynamics; Permeation models
dc.titlePhysics of Ion Channels
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume29
dc.date.issued2003
local.identifier.absfor029901 - Biological Physics
local.identifier.ariespublicationMigratedxPub17024
local.type.statusPublished Version
local.contributor.affiliationKuyucak, Serdar, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationBastug, Turgut, College of Physical and Mathematical Sciences, ANU
local.bibliographicCitation.startpage429
local.bibliographicCitation.lastpage446
local.identifier.doi10.1023/A:1027309113522
dc.date.updated2015-12-12T08:28:07Z
local.identifier.scopusID2-s2.0-0345307243
CollectionsANU Research Publications

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