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Role of the p70S6K pathway in regulating the actin cytoskeleton and cell migration

Berven, Leise; Willard, Francis; Crouch, Michael F


We have examined the role of endogenous 70-kDa S6 kinase (p70 S6K) in actin cytoskeletal organization and cell migration in Swiss 3T3 fibroblasts. Association of p70S6K with the actin cytoskeleton was demonstrated by cosedimentation of p70S6K with F-actin and by subcellular fractionation in which p70S6K activity was measured in the F-actin cytoskeletal fraction. Immunocytochemical studies showed that p70S6K, Akt1, PDK1, and p85 phosphoinositide 3-kinase (PI 3-kinase) were localized to the actin...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Experimental Cell Research
DOI: 10.1016/j.yexcr.2003.12.032


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