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Effects of NMDA receptor antagonists on olfactory learning and memory in the honeybee

Si, Aung; Helliwell, Paul; Maleszka, Ryszard

Description

In contrast to vertebrates the involvement of glutamate and N-methyl-D-aspartate (NMDA) receptors in brain functions in insects is both poorly understood and somewhat controversial. Here, we have examined the behavioural effects of two noncompetitive NMDA receptor antagonists, memantine (low affinity) and MK-801 (high affinity), on learning and memory in honeybees (Apis mellifera) using the olfactory conditioning of the proboscis extension reflex (PER). We induced memory deficit by injecting...[Show more]

dc.contributor.authorSi, Aung
dc.contributor.authorHelliwell, Paul
dc.contributor.authorMaleszka, Ryszard
dc.date.accessioned2015-12-13T23:11:17Z
dc.identifier.issn0091-3057
dc.identifier.urihttp://hdl.handle.net/1885/87524
dc.description.abstractIn contrast to vertebrates the involvement of glutamate and N-methyl-D-aspartate (NMDA) receptors in brain functions in insects is both poorly understood and somewhat controversial. Here, we have examined the behavioural effects of two noncompetitive NMDA receptor antagonists, memantine (low affinity) and MK-801 (high affinity), on learning and memory in honeybees (Apis mellifera) using the olfactory conditioning of the proboscis extension reflex (PER). We induced memory deficit by injecting harnessed individuals with a glutamate transporter inhibitor, L-trans-2,4-PDC (L-trans-2,4-pyrrolidine dicarboxylate), that impairs long-term (24 h), but not short-term (1 h), memory in honeybees. We show that L-trans-2,4-PDC-induced amnesia is 'rescued' by memantine injected either before training, or before testing, suggesting that memantine restores memory recall rather than memory formation or storage. When injected alone memantine has a mild facilitating effect on memory. The effects of MK-801 are similar to those of L-trans-2,4-PDC. Both pretraining and pretesting injections lead to an impairment of long-term (24 h) memory, but have no effect on short-term (1 h) memory of an olfactory task. The implications of our results for memory processes in the honeybee are discussed.
dc.publisherPergamon-Elsevier Ltd
dc.sourcePharmacology Biochemistry and Behavior
dc.subjectKeywords: 2,4 pyrrolidinedicarboxylic acid; dizocilpine; glutamate transporter; memantine; n methyl dextro aspartic acid receptor blocking agent; amnesia; animal experiment; animal model; article; behavior; conditioning; controlled study; dose response; drug effect Associative learning; Glutamate; Long-term memory; Memantine; MK-801; Mushroom bodies; Proboscis conditioning
dc.titleEffects of NMDA receptor antagonists on olfactory learning and memory in the honeybee
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume77
dc.date.issued2004
local.identifier.absfor110906 - Sensory Systems
local.identifier.ariespublicationMigratedxPub16863
local.type.statusPublished Version
local.contributor.affiliationSi, Aung, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationHelliwell, Paul, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMaleszka, Ryszard, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage191
local.bibliographicCitation.lastpage197
local.identifier.doi10.1016/j.pbb.2003.09.023
dc.date.updated2015-12-12T08:26:51Z
local.identifier.scopusID2-s2.0-1642493766
CollectionsANU Research Publications

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