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Effects of NMDA receptor antagonists on olfactory learning and memory in the honeybee

Si, Aung; Helliwell, Paul; Maleszka, Ryszard


In contrast to vertebrates the involvement of glutamate and N-methyl-D-aspartate (NMDA) receptors in brain functions in insects is both poorly understood and somewhat controversial. Here, we have examined the behavioural effects of two noncompetitive NMDA receptor antagonists, memantine (low affinity) and MK-801 (high affinity), on learning and memory in honeybees (Apis mellifera) using the olfactory conditioning of the proboscis extension reflex (PER). We induced memory deficit by injecting...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Pharmacology Biochemistry and Behavior
DOI: 10.1016/j.pbb.2003.09.023


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