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Proteolytic processing of the Mycoplasma hyopneumoniae cilium adhesin

Djorgovski, S G; Cordwell, Stuart J; Djordjevic, Michael; Wilton, Jody; Minion, F


Mycoplasma hyopneumoniae is an economically significant swine pathogen that colonizes the respiratory ciliated epithelial cells. Cilium adherence is mediated by P97, a surface protein containing a repeating element (R1) that is responsible for binding. Here, we show that the cilium adhesin is proteolytically processed on the surface. Proteomic analysis of strain J proteins identified cleavage products of 22, 28, 66, and 94 kDa. N-terminal sequencing showed that the 66- and 94-kDa proteins...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Infection and Immunity
DOI: 10.1128/IAI.72.5.2791-2802.2004


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