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Two major classes of target site insensitivity mutations confer resistance to organophosphate and carbamate insecticides

Russell, Robyn; Claudianos, Charles; Campbell, Peter M; Horne, Irene; Sutherland, Tara D; Oakeshott, John Graham

Description

Interspecific comparisons of bioassay and biochemical data suggest two major patterns of target site resistance to carbamates and organophosphates. Pattern I resistance, which is generally more effective for carbamates, has been shown in two sub-species of mosquitoes to be due to a particular Gly-Ser mutation in the oxyanion hole within the active site of one of their two acetylcholinesterase enzymes. Intriguingly, different substitutions at the equivalent site confer organophosphate hydrolytic...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/87030
Source: Pesticide Biochemistry and Physiology
DOI: 10.1016/j.pestbp.2004.03.002

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