Skip navigation
Skip navigation

Two major classes of target site insensitivity mutations confer resistance to organophosphate and carbamate insecticides

Russell, Robyn; Claudianos, Charles; Campbell, Peter M; Horne, Irene; Sutherland, Tara D; Oakeshott, John Graham


Interspecific comparisons of bioassay and biochemical data suggest two major patterns of target site resistance to carbamates and organophosphates. Pattern I resistance, which is generally more effective for carbamates, has been shown in two sub-species of mosquitoes to be due to a particular Gly-Ser mutation in the oxyanion hole within the active site of one of their two acetylcholinesterase enzymes. Intriguingly, different substitutions at the equivalent site confer organophosphate hydrolytic...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Pesticide Biochemistry and Physiology
DOI: 10.1016/j.pestbp.2004.03.002


File Description SizeFormat Image
01_Russell_Two_major_classes_of_target_2004.pdf204.66 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator