Evidence that the lichen-derived scabrosin esters target mitochondrial ATP synthase in P388DI cells
Scabrosin esters (SEs), which have been recently isolated from the lichen Xanthoparmelia scabrosa, belong to the epipolythiodioxopiperazine (ETP) class of secondary metabolites characterized by possession of a reactive disulfide bond. Colony forming assays show that these toxins are active against human tumor cell lines at nanomolar concentrations. Other members of the ETP class of toxins such as gliotoxin have been shown to induce apoptosis in cells, although the cellular target(s) of the ETP...[Show more]
|Collections||ANU Research Publications|
|Source:||Toxicology and Applied Pharmacology|
|01_Moerman_Evidence_that_the_2003.pdf||319.72 kB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.