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Evidence that the lichen-derived scabrosin esters target mitochondrial ATP synthase in P388DI cells

Moerman, Katherine; Chai, Christina; Waring, Paul


Scabrosin esters (SEs), which have been recently isolated from the lichen Xanthoparmelia scabrosa, belong to the epipolythiodioxopiperazine (ETP) class of secondary metabolites characterized by possession of a reactive disulfide bond. Colony forming assays show that these toxins are active against human tumor cell lines at nanomolar concentrations. Other members of the ETP class of toxins such as gliotoxin have been shown to induce apoptosis in cells, although the cellular target(s) of the ETP...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Toxicology and Applied Pharmacology
DOI: 10.1016/S0041-008X(03)00189-3


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