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Citron kinase is an essential effector of the Pbl-activated Rho signalling pathway in Drosophila melanogaster

Shandala, Tetyana; Gregory, Stephen L; Dalton, Hazel E; Smallhorn, M; Saint, Robert

Description

Pebble (Pbl)-activated RhoA signalling is essential for cytokinesis in Drosophila melanogaster. Here we report that the Drosophila citron gene encodes an essential effector kinase of Pbl-RhoA signalling in vivo. Drosophila citron is expressed in proliferating tissues but is downregulated in differentiating tissues. We find that Citron can bind RhoA and that localisation of Citron to the contractile ring is dependent on the cytokinesis-specific Pbl-RhoA signalling. Phenotypic analysis of mutants...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/86805
Source: Development
DOI: 10.1242/dev.01382

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