Therapeutic LMP1 polyepitope vaccine for EBV-associated Hodgkin disease and nasopharyngeal carcinoma
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Duraiswamy, Jai; Sherritt, Martina; Thomson, Scott; Tellam, Judy; Cooper, Leanne; Connolly, Geoff; Bharadwaj, M; Khanna, Rajiv
Description
Development of an epitope-based vaccination strategy designed to enhance Epstein-Barr virus (EBV)-specific CD8+ cytotoxic T lymphocytes (CTLs) is increasingly being considered as a preferred approach for the treatment of EBV-associated relapsed Hodgkin disease (HD) and nasopharyngeal carcinoma (NPC). EBV-encoded latent membrane proteins, LMP1 and LMP2, are the only target antigens available for therapeutic augmentation of CTL responses in patients with HD and NPC. Here, we describe preclinical...[Show more]
Collections | ANU Research Publications |
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Date published: | 2003 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/86734 |
Source: | Blood |
DOI: | 10.1182/blood-2002-10-3092 |
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File | Description | Size | Format | Image |
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01_Duraiswamy_Therapeutic_LMP1_polyepitope_2003.pdf | 345.14 kB | Adobe PDF | Request a copy |
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