Duraiswamy, Jai; Sherritt, Martina; Thomson, Scott; Tellam, Judy; Cooper, Leanne; Connolly, Geoff; Bharadwaj, M; Khanna, Rajiv
Development of an epitope-based vaccination strategy designed to enhance Epstein-Barr virus (EBV)-specific CD8+ cytotoxic T lymphocytes (CTLs) is increasingly being considered as a preferred approach for the treatment of EBV-associated relapsed Hodgkin disease (HD) and nasopharyngeal carcinoma (NPC). EBV-encoded latent membrane proteins, LMP1 and LMP2, are the only target antigens available for therapeutic augmentation of CTL responses in patients with HD and NPC. Here, we describe preclinical...[Show more]
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