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Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D

McColl, Bradley K; Baldwin, Megan E; Roufail, Sally; Freeman, Craig; Moritz, Robert L; Simpson, Richard J; Alitalo, Kari; Stacker, Steven A; Achen, Marc G

Description

Vascular endothelial growth factor (VEGF) C and VEGF-D stimulate lymphangiogenesis and angiogenesis in tissues and tumors by activating the endothelial cell surface receptor tyrosine kinases VEGF receptor (VEGFR) 2 and VEGFR-3. These growth factors are secreted as full-length inactive forms consisting of NH2- and COOH-terminal propeptides and a central VEGF homology domain (VHD) containing receptor binding sites. Proteolytic cleavage removes the propeptides to generate mature forms, consisting...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
URI: http://hdl.handle.net/1885/86705
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.20030361

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