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KIR2DL4 (CD158d) genotype influences expression and function in NK cells

Goodridge, Jodie; Witt, Campbell; Christiansen, Frank; Warren, Hilary


The expression and function of the NK cell receptor KIR2DL4 are controversial. Two common alleles of the transmembrane domain of KIR2DL4 exist. The 10A allele with 10 adenines at the end of the transmembrane exon encodes a full length receptor, whereas the 9A allele has only 9 adenines resulting in a frame shift which in turn generates a stop codon early in the first cytoplasmic exon. The possibility that the 10A and 9A alleles might result in differences in expression and function of KIR2DL4...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Immunology


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