Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis
Jun, Jesse; Wilson, Lauren; Garcia De Vinuesa, Maria Carola; Lesage, Sylvie; Blery, Mathieu; Miosge, Lisa; Cook, Matthew C; Kucharska, Edyta; Hara, H; Penninger, Josef; Domaschenz, Heather; Hong, Nancy A; Glynne, Richard; Nelms, Keats; Goodnow, Christopher
In a genome-wide ENU mouse mutagenesis screen a recessive mouse mutation, unmodulated, was isolated with profound defects in humoral immune responses, selective deficits in B cell activation by antigen receptors and T cell costimulation by CD28, and gradual development of atopic dermatitis with hyper-IgE. Mutant B cells are specifically defective in forming connections between antigen receptors and two key signaling pathways for immunogenic responses, NF-κB and JNK, but signal normally to...[Show more]
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