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The pathophysiology of falciparum malaria

Clark, Ian A; Cowden, William


Falciparum malaria is a complex disease with no simple explanation, affecting organs where the parasite is rare as well as those organs where it is more common. We continue to argue that it can best be understood in terms of excessive stimulation of normally useful pathways mediated by inflammatory cytokines, the prototype being tumor necrosis factor (TNF). These pathways involve downstream mediators, such as nitric oxide (NO) that the host normally uses to control parasites, but which, when...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Pharmacology and Therapeutics
DOI: 10.1016/S0163-7258(03)00060-3


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