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CTLA-4 and its role in autoimmune thyroid disease

Chistiakov, D A; Turakulov, R


Autoimmune thyroid disease (AITD) occurs in two common forms: Graves' disease and Hashimoto thyroiditis. On the basis of functional and experimental data, it has been suggested that the gene encoding cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is a candidate gene for conferring susceptibility to thyroid autoimmunity. In this review, we critically evaluate the evidence for pathogenetic involvement of CTLA-4 in the various forms of AITD and focus on the possible role of genetic variation...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Molecular Endocrinology
DOI: 10.1677/jme.0.0310021


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