CTLA-4 and its role in autoimmune thyroid disease
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Autoimmune thyroid disease (AITD) occurs in two common forms: Graves' disease and Hashimoto thyroiditis. On the basis of functional and experimental data, it has been suggested that the gene encoding cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is a candidate gene for conferring susceptibility to thyroid autoimmunity. In this review, we critically evaluate the evidence for pathogenetic involvement of CTLA-4 in the various forms of AITD and focus on the possible role of genetic variation...[Show more]
dc.contributor.author | Chistiakov, D A | |
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dc.contributor.author | Turakulov, R | |
dc.date.accessioned | 2015-12-13T23:08:16Z | |
dc.date.available | 2015-12-13T23:08:16Z | |
dc.identifier.issn | 0952-5041 | |
dc.identifier.uri | http://hdl.handle.net/1885/86601 | |
dc.description.abstract | Autoimmune thyroid disease (AITD) occurs in two common forms: Graves' disease and Hashimoto thyroiditis. On the basis of functional and experimental data, it has been suggested that the gene encoding cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is a candidate gene for conferring susceptibility to thyroid autoimmunity. In this review, we critically evaluate the evidence for pathogenetic involvement of CTLA-4 in the various forms of AITD and focus on the possible role of genetic variation of the CTLA4 locus. Population genetics data strongly suggest a role for the CTLA4 region in susceptibility to AITD. However, further functional studies are required to understand the significance of CTLA4 polymorphisms in the pathogenic mechanism of AITD. | |
dc.publisher | Society for Endocrinology | |
dc.source | Journal of Molecular Endocrinology | |
dc.subject | Keywords: cytotoxic T lymphocyte antigen 4; autoimmune disease; gene locus; genetic code; genetic polymorphism; genetic susceptibility; genetic variability; Graves disease; Hashimoto disease; human; nonhuman; pathogenesis; population genetics; priority journal; rev | |
dc.title | CTLA-4 and its role in autoimmune thyroid disease | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.description.refereed | Yes | |
local.identifier.citationvolume | 31 | |
dc.date.issued | 2003 | |
local.identifier.absfor | 110703 - Autoimmunity | |
local.identifier.ariespublication | MigratedxPub15515 | |
local.type.status | Published Version | |
local.contributor.affiliation | Chistiakov, D A, Catholic University of Leuven | |
local.contributor.affiliation | Turakulov, R, College of Medicine, Biology and Environment, ANU | |
local.bibliographicCitation.startpage | 21 | |
local.bibliographicCitation.lastpage | 36 | |
local.identifier.doi | 10.1677/jme.0.0310021 | |
dc.date.updated | 2015-12-12T08:12:51Z | |
local.identifier.scopusID | 2-s2.0-0042353836 | |
Collections | ANU Research Publications |
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