Skip navigation
Skip navigation

CTLA-4 and its role in autoimmune thyroid disease

Chistiakov, D A; Turakulov, R

Description

Autoimmune thyroid disease (AITD) occurs in two common forms: Graves' disease and Hashimoto thyroiditis. On the basis of functional and experimental data, it has been suggested that the gene encoding cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is a candidate gene for conferring susceptibility to thyroid autoimmunity. In this review, we critically evaluate the evidence for pathogenetic involvement of CTLA-4 in the various forms of AITD and focus on the possible role of genetic variation...[Show more]

dc.contributor.authorChistiakov, D A
dc.contributor.authorTurakulov, R
dc.date.accessioned2015-12-13T23:08:16Z
dc.date.available2015-12-13T23:08:16Z
dc.identifier.issn0952-5041
dc.identifier.urihttp://hdl.handle.net/1885/86601
dc.description.abstractAutoimmune thyroid disease (AITD) occurs in two common forms: Graves' disease and Hashimoto thyroiditis. On the basis of functional and experimental data, it has been suggested that the gene encoding cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is a candidate gene for conferring susceptibility to thyroid autoimmunity. In this review, we critically evaluate the evidence for pathogenetic involvement of CTLA-4 in the various forms of AITD and focus on the possible role of genetic variation of the CTLA4 locus. Population genetics data strongly suggest a role for the CTLA4 region in susceptibility to AITD. However, further functional studies are required to understand the significance of CTLA4 polymorphisms in the pathogenic mechanism of AITD.
dc.publisherSociety for Endocrinology
dc.sourceJournal of Molecular Endocrinology
dc.subjectKeywords: cytotoxic T lymphocyte antigen 4; autoimmune disease; gene locus; genetic code; genetic polymorphism; genetic susceptibility; genetic variability; Graves disease; Hashimoto disease; human; nonhuman; pathogenesis; population genetics; priority journal; rev
dc.titleCTLA-4 and its role in autoimmune thyroid disease
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume31
dc.date.issued2003
local.identifier.absfor110703 - Autoimmunity
local.identifier.ariespublicationMigratedxPub15515
local.type.statusPublished Version
local.contributor.affiliationChistiakov, D A, Catholic University of Leuven
local.contributor.affiliationTurakulov, R, College of Medicine, Biology and Environment, ANU
local.bibliographicCitation.startpage21
local.bibliographicCitation.lastpage36
local.identifier.doi10.1677/jme.0.0310021
dc.date.updated2015-12-12T08:12:51Z
local.identifier.scopusID2-s2.0-0042353836
CollectionsANU Research Publications

Download

There are no files associated with this item.


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator