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DNA binding of the anti-cancer platinum complex trans -[{Pt(NH 3 ) 2 Cl} 2 μ-dpzm] 2+

Wheate, Nial; Evison, Ben; Herlt, Anthony; Phillips, Don; Collins, John


The DNA binding of the dinuclear platinum complex trans-[{Pt(NH 3)2Cl}2μ-dpzm]2+ (di-Pt), linked with the 4,4′-dipyrazolylmethane (dpzm) linker, was examined by 1H and 195Pt NMR and transcription assays. At 60 °C, di-Pt reacts with guanosine two-fold

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Dalton Transactions


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