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A biotin derivative blocks parasite induced novel permeation pathways in Plasmodium falciparum -infected erythrocytes

Baumeister, Stefan; Endermann, Tobias; Charpian, Stefan; Nyalwidhe, Julius; Duranton, Christophe; Huber, Stephan J; Kirk, Kiaran; Lang, Florian; Lingelbach, Klaus

Description

The malaria parasite Plasmodium falciparum infects human erythrocytes, and it induces an increased rate of uptake into the infected cell of a range of solutes, including essential nutrients required for parasite development. Several models have been proposed for the mechanism(s) underlying parasite-induced solute uptake, each differing with respect to the site of entry into infected cells. We show that a biotin derivative that is excluded from non-infected erythrocytes gains access to infected...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
URI: http://hdl.handle.net/1885/86566
Source: Molecular and Biochemical Parasitology
DOI: 10.1016/j.molbiopara.2003.08.003

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