A biotin derivative blocks parasite induced novel permeation pathways in Plasmodium falciparum -infected erythrocytes
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Baumeister, Stefan; Endermann, Tobias; Charpian, Stefan; Nyalwidhe, Julius; Duranton, Christophe; Huber, Stephan J; Kirk, Kiaran; Lang, Florian; Lingelbach, Klaus
Description
The malaria parasite Plasmodium falciparum infects human erythrocytes, and it induces an increased rate of uptake into the infected cell of a range of solutes, including essential nutrients required for parasite development. Several models have been proposed for the mechanism(s) underlying parasite-induced solute uptake, each differing with respect to the site of entry into infected cells. We show that a biotin derivative that is excluded from non-infected erythrocytes gains access to infected...[Show more]
Collections | ANU Research Publications |
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Date published: | 2003 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/86566 |
Source: | Molecular and Biochemical Parasitology |
DOI: | 10.1016/j.molbiopara.2003.08.003 |
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