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Antibody response in the female rabbit reproductive tract to influenza haemagglutinin encoded by a recombinant myxoma virus

Gu, Wenyi; Holland, Michael; Janssens, Peter; Kerr, Peter

Description

The antibody response in serum and the reproductive tract of female rabbits to a model antigen, influenza virus haemagglutinin (HA), encoded by a recombinant myxoma virus was investigated. Strong and lasting IgG antibody responses to HA were induced in serum following intradermal, intranasal, and intravaginal immunisations. HA IgG was also detected in reproductive tract fluids but was only about 1% the titer of that in serum. HA IgA was not detected in serum of any infected groups and was...[Show more]

dc.contributor.authorGu, Wenyi
dc.contributor.authorHolland, Michael
dc.contributor.authorJanssens, Peter
dc.contributor.authorKerr, Peter
dc.date.accessioned2015-12-13T23:08:12Z
dc.date.available2015-12-13T23:08:12Z
dc.identifier.issn0042-6822
dc.identifier.urihttp://hdl.handle.net/1885/86565
dc.description.abstractThe antibody response in serum and the reproductive tract of female rabbits to a model antigen, influenza virus haemagglutinin (HA), encoded by a recombinant myxoma virus was investigated. Strong and lasting IgG antibody responses to HA were induced in serum following intradermal, intranasal, and intravaginal immunisations. HA IgG was also detected in reproductive tract fluids but was only about 1% the titer of that in serum. HA IgA was not detected in serum of any infected groups and was occasionally detected in reproductive tract fluids at a low titer only after infections through mucosal sites. HA IgM was also detected only in some of the reproductive tract fluids at very low levels. Induction of ovulation did not change these patterns and B cell homing to the reproductive tract was not profound. In contrast, HA IgG and IgM titers in ovarian follicular fluids were comparable to that in serum. These data suggest that if this virus is used to deliver an immunocontraceptive vaccine that requires a high-level antibody response, the target antigen needs to be accessible to serum antibody or in the ovary.
dc.publisherAcademic Press
dc.sourceVirology
dc.subjectKeywords: hemagglutinin; immunoglobulin G; immunoglobulin M; Influenza virus hemagglutinin; animal experiment; animal tissue; antibody blood level; antibody response; antibody titer; antigen detection; article; B lymphocyte; comparative study; controlled study; dat Antibody response; Female genital tract; Recombinant myxoma virus
dc.titleAntibody response in the female rabbit reproductive tract to influenza haemagglutinin encoded by a recombinant myxoma virus
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume313
dc.date.issued2003
local.identifier.absfor060506 - Virology
local.identifier.ariespublicationMigratedxPub15478
local.type.statusPublished Version
local.contributor.affiliationGu, Wenyi, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationHolland, Michael, CSIRO
local.contributor.affiliationJanssens, Peter, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKerr, Peter, College of Medicine, Biology and Environment, ANU
local.bibliographicCitation.issue1
local.bibliographicCitation.startpage286
local.bibliographicCitation.lastpage295
local.identifier.doi10.1016/S0042-6822(03)00324-6
dc.date.updated2015-12-12T08:12:34Z
local.identifier.scopusID2-s2.0-0041887447
CollectionsANU Research Publications

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