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Comparison of fluorotyrosines and methionine uptake in F98 rat gliomas

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Langen, Karl-Josef; Jarosch, M; Muhlensiepen, Heinz; Hamacher, Kurt; Broer, Stefan; Jansen, Paul; Zilles, Karl; Coenen, Heinz

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The transport mechanisms of O-(2-[18F]fluoroethyl)-L-tyrosine (FET) and 2-[18F]fluoro-L-tyrosine (FTyr) were compared to those of [3H]-Methyl-L-methionine (MET) in F98 rat glioma cells in vitro and by tumor imaging by ex vivo dual tracer autoradiography in F98 rat gliomas. Both, FET and FTyr exhibited similar transport characteristics in F98 glioma cells compared to MET, i.e. mainly a sodium dependent transport similar to system B0,+ and sodium independent transport via system L. Radioactivity...[Show more]

dc.contributor.authorLangen, Karl-Josef
dc.contributor.authorJarosch, M
dc.contributor.authorMuhlensiepen, Heinz
dc.contributor.authorHamacher, Kurt
dc.contributor.authorBroer, Stefan
dc.contributor.authorJansen, Paul
dc.contributor.authorZilles, Karl
dc.contributor.authorCoenen, Heinz
dc.date.accessioned2015-12-13T23:08:12Z
dc.date.available2015-12-13T23:08:12Z
dc.identifier.issn0969-8051
dc.identifier.urihttp://hdl.handle.net/1885/86564
dc.description.abstractThe transport mechanisms of O-(2-[18F]fluoroethyl)-L-tyrosine (FET) and 2-[18F]fluoro-L-tyrosine (FTyr) were compared to those of [3H]-Methyl-L-methionine (MET) in F98 rat glioma cells in vitro and by tumor imaging by ex vivo dual tracer autoradiography in F98 rat gliomas. Both, FET and FTyr exhibited similar transport characteristics in F98 glioma cells compared to MET, i.e. mainly a sodium dependent transport similar to system B0,+ and sodium independent transport via system L. Radioactivity of FET in the acid precipitable fraction was <1% after 120 min incubation time while FTyr and MET exhibited a 15-18% incorporation into proteins. Comparison of FET and FTyr with MET uptake in F98 rat gliomas demonstrated a significant correlation of tumor to brain ratios and a similar intratumoral tracer distribution pattern.
dc.publisherElsevier
dc.sourceNuclear Medicine and Biology
dc.subjectKeywords: 2 aminobicyclo[2.2.1]heptane 2 carboxylic acid; 2 fluorotyrosine f 18; 2 methyl 2 methylaminopropionic acid; acid; alpha methylmethionine h 3; methionine derivative; o (2 fluoroethyl)tyrosine f 18; protein; serine; sodium; tracer; tyrosine derivative; unc 2-[18F]fluoro-L-tyrosine (FTyr); [3H]-Methyl-L-methionine (MET); F98-glioma cells; O-(2-[18F]fluoroethyl)-L-tyrosine (FET); PET; Radiolabelled amino acids
dc.titleComparison of fluorotyrosines and methionine uptake in F98 rat gliomas
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume30
dc.date.issued2003
local.identifier.absfor060105 - Cell Neurochemistry
local.identifier.ariespublicationMigratedxPub15477
local.type.statusPublished Version
local.contributor.affiliationLangen, Karl-Josef, Research Center Julich
local.contributor.affiliationJarosch, M, Institute of Medicine, Research Centre
local.contributor.affiliationMuhlensiepen, Heinz, Research Center Julich
local.contributor.affiliationHamacher, Kurt, Research Center Julich
local.contributor.affiliationBroer, Stefan, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationJansen, Paul, Research Center Julich
local.contributor.affiliationZilles, Karl, Research Center Julich
local.contributor.affiliationCoenen, Heinz, Research Center Julich
local.bibliographicCitation.issue5
local.bibliographicCitation.startpage501
local.bibliographicCitation.lastpage508
local.identifier.doi10.1016/S0969-8051(03)00023-4
dc.date.updated2015-12-12T08:12:34Z
local.identifier.scopusID2-s2.0-0037756793
CollectionsANU Research Publications

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