Skip navigation
Skip navigation

Regulation of cytosolic pH and lactic acid release in mesangial cells overexpressing GLUT1

Lang, Karl; Mueller, Matthias; Tanneur, Valerie; Wallisch, Sabine; Fedorenko, Olga; Palmada, Monica; Lang, Florian; Broer, Stefan; Heilig, Charles; Schleicher, Erwin; Weigert, Cora

Description

Background. Anaerobic glycolysis leads to the formation of lactate and H+ and thus imposes a significant challenge on cytosolic acid/base regulation. Cytosolic acidification, on the other hand, is known to inhibit flux through glycolysis and lactate formation. To explore the interplay of cytosolic pH and glycolysis, rat mesangial cells transfected with the glucose transporter GLUT1 (GLUT1 cells) were compared with those transfected with β-galactosidase (LacZ cells). Methods. In the presence of...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
URI: http://hdl.handle.net/1885/86553
Source: Kidney International
DOI: 10.1046/j.1523-1755.2003.00213.x

Download

There are no files associated with this item.


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator