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Properties and regulation of glutamine transporter SN1 by protein kinases SGK and PKB

Boehmer, C; Okur, Ferah; Setiawan, Iwan; Broer, Stefan; Lang, Florian

Description

The amino acid transporter SN1 with substrate specificity identical to the amino acid transport system N is expressed mainly in astrocytes and hepatocytes where it accomplishes Na+-coupled glutamine uptake and efflux. To characterize properties and regulation of SN1, substrate-induced currents and/or radioactive glutamine uptake were determined in Xenopus oocytes injected with cRNA encoding SN1, the ubiquitin ligase Nedd4-2, and/or the constitutively active serum and glucocorticoid inducible...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
URI: http://hdl.handle.net/1885/86549
Source: Biochemical and Biophysical Research Communications
DOI: 10.1016/S0006-291X(03)00921-5

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