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Glutamine efflux from astrocytes is mediated by multiple pathways

Deitmer, J; Broer, Angelika; Broer, Stefan


The neurotransmitter glutamate, once released into the synaptic cleft, is largely recycled by the glutamate-glutamine cycle, which involves uptake into astrocytes, conversion into glutamine and subsequent release of glutamine from astrocytes as a precursor for neuroneal glutamate synthesis. We analysed glutamine efflux from cultured astrocytes by pre-loading cells with labelled glutamine for 30 min and subsequently measured glutamine efflux for 30 min. Efflux of preloaded glutamine was rapid...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Neurochemistry
DOI: 10.1046/j.1471-4159.2003.01981.x


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