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Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and the protein kinase B

Boehmer, C; Henke, Guido; Schniepp, Roman; Palmada, Monica; Rothstein, Jeffrey; Broer, Stefan; Lang, Florian


Surface expression of the glial glutamate transporter EAAT1 is stimulated by insulin-like growth factor 1 through activation of phosphatidylinositol-3-kinase. Downstream targets include serum and glucocorticoid-sensitive kinase isoforms SGK1, SGK2 and SGK3, and protein kinase B. SGK1 regulates Nedd4-2, a ubiquitin ligase that prepares cell membrane proteins for degradation. To test whether Nedd4-2, SGK1, SGK3 and protein kinase B regulate EAAT1, cRNA encoding EAAT1 was injected into Xenopus...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Neurochemistry


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