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Acidification of the Malaria Parasites Digestive Vacuole by a H + -ATPase and a H + -pyrophosphatase

Saliba, Kevin; Allen, Richard; Zissis, S; Bray, Patrick; Ward, Stephen A; Kirk, Kiaran


As it grows within the human erythrocyte, the malaria parasite, Plasmodium falciparum, ingests the erythrocyte cytosol, depositing it via an endocytotic feeding mechanism in the "digestive vacuole," a specialized acidic organelle. The digestive vacuole is the site of hemoglobin degradation, the storage site for hemozoin (an inert biocrystal of toxic heme), the site of action of many antimalarial drugs, and the site of proteins known to be involved in antimalarial drug resistance. The acidic pH...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M208648200


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