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Asymmetry of glutamine transporters in cultured neural cells

Henckel, Timo; Broer, Angelika; Wiesinger, H; Lang, Florian; Broer, Stefan

Description

Transfer of glutamine between astrocytes and neurons is an essential part of the glutamate-glutamine cycle in the brain. Transport of glutamine was investigated in primary cultures of astrocytes and neurons and compared to glutamine transport in cell lines with glial and neuronal properties. Glutamine uptake in astrocytes was mainly mediated by general amino acid transporters with properties similar to ASCT2, LAT1, LAT2, SN1 and y+LAT2. In cultured neurons, transport activities were detected...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
URI: http://hdl.handle.net/1885/86488
Source: Neurochemistry International
DOI: 10.1016/S0197-0186(03)00014-7

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