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MHC Class II Molecules Play a Role in the Selection of Autoreactive Class I-Restricted CD8 T Cells That Are Essential Contributors to Type 1 Diabetes Development in Nonobese Diabetic Mice

Serreze, David; Holl, T. Matthew; Marron, Michele; Graser, Robert; Johnson, Ellis; Choisy-Rossi, Caroline; Slattery, Robyn; Lieberman, Scott; DiLorenzo, Teresa


Development of autoreactive CD4 T cells contributing to type 1 diabetes (T1D) in both humans and nonobese diabetic (NOD) mice is either promoted or dominantly inhibited by particular MHC class II variants. In addition, it is now clear that when co-expressed with other susceptibility genes, some common MHC class I variants aberrantly mediate autoreactive CD8 T cell responses also essential to T1D development. However, it was unknown whether the development of diabetogenic CD8 T cells could also...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of Immunology


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