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Conformation of Prion Protein Repeat Peptides Probed by FRET Measurements and Molecular Dynamics Simulations

Gustiananda, Marsia; Liggins, John; Cummins, Peter; Gready, Jill

Description

We report the combined use of steady-state fluorescence resonance energy transfer (FRET) experiments and molecular dynamics (MD) simulations to investigate conformational distributions of the prion protein (PrP) repeat system. FRET was used for the first

dc.contributor.authorGustiananda, Marsia
dc.contributor.authorLiggins, John
dc.contributor.authorCummins, Peter
dc.contributor.authorGready, Jill
dc.date.accessioned2015-12-13T23:07:44Z
dc.identifier.issn0006-3495
dc.identifier.urihttp://hdl.handle.net/1885/86335
dc.description.abstractWe report the combined use of steady-state fluorescence resonance energy transfer (FRET) experiments and molecular dynamics (MD) simulations to investigate conformational distributions of the prion protein (PrP) repeat system. FRET was used for the first
dc.publisherBiophysical Society
dc.sourceBiophysical Journal
dc.subjectKeywords: cation; dansyl chloride; histidine; peptide; phenylalanine; prion protein; tryptophan; anisotropy; article; fluorescence resonance energy transfer; marsupial; molecular dynamics; pH; protein conformation; simulation; temperature; Amino Acid Sequence; Anim
dc.titleConformation of Prion Protein Repeat Peptides Probed by FRET Measurements and Molecular Dynamics Simulations
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume86
dc.date.issued2004
local.identifier.absfor060199 - Biochemistry and Cell Biology not elsewhere classified
local.identifier.absfor030606 - Structural Chemistry and Spectroscopy
local.identifier.absfor030799 - Theoretical and Computational Chemistry not elsewhere classified
local.identifier.ariespublicationMigratedxPub15177
local.type.statusPublished Version
local.contributor.affiliationGustiananda, Marsia, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationLiggins, John, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationCummins, Peter, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGready, Jill, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage2467
local.bibliographicCitation.lastpage2483
dc.date.updated2015-12-12T08:10:27Z
local.identifier.scopusID2-s2.0-1942519322
CollectionsANU Research Publications

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