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Functional polymorphism of human glutathione transferase A3: effects on xenobiotic metabolism and steroid biosynthesis

Tetlow, Natasha; Coggan, Marjorie; Casarotto, Marco; Board, Philip

Description

The alpha class glutathione transferase GSTA3-3 is involved in steroid biosynthesis and the metabolism of some xenobiotics. A bioinformatics approach was utilized to identify novel coding region polymorphisms in the glutathione transferase A3 gene (GSTA3). We describe an I71L polymorphism in GSTA3 that occurs at a low frequency in African populations. The activity of the leucine containing isoform was significantly reduced in a range of glutathione- conjugating reactions due to a diminished...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/86323
Source: Pharmacogenetics and Genomics
DOI: 10.1097/00008571-200410000-00003

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