Functional polymorphism of human glutathione transferase A3: effects on xenobiotic metabolism and steroid biosynthesis
The alpha class glutathione transferase GSTA3-3 is involved in steroid biosynthesis and the metabolism of some xenobiotics. A bioinformatics approach was utilized to identify novel coding region polymorphisms in the glutathione transferase A3 gene (GSTA3). We describe an I71L polymorphism in GSTA3 that occurs at a low frequency in African populations. The activity of the leucine containing isoform was significantly reduced in a range of glutathione- conjugating reactions due to a diminished...[Show more]
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|Source:||Pharmacogenetics and Genomics|
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