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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kB signalling

Wen, S; O'Rourke, Karen; Zhou, Honglin; Eby, Michael; Aravind, L; Seshagiri, Somasekar; Wu, Ping-Shi; Wiesmann, Christian; Baker, Rohan; Boone, David; Ma, Averil; Koonin, Eugene; Dixit, Vishva

Description

NF-κB transcription factors mediate the effects of pro-inflammatory cytokines such as tumour necrosis factor-α and interleukin-1β. Failure to downregulate NF-κB transcriptional activity results in chronic inflammation and cell death, as observed in A2

dc.contributor.authorWen, S
dc.contributor.authorO'Rourke, Karen
dc.contributor.authorZhou, Honglin
dc.contributor.authorEby, Michael
dc.contributor.authorAravind, L
dc.contributor.authorSeshagiri, Somasekar
dc.contributor.authorWu, Ping-Shi
dc.contributor.authorWiesmann, Christian
dc.contributor.authorBaker, Rohan
dc.contributor.authorBoone, David
dc.contributor.authorMa, Averil
dc.contributor.authorKoonin, Eugene
dc.contributor.authorDixit, Vishva
dc.date.accessioned2015-12-13T23:07:42Z
dc.identifier.issn0028-0836
dc.identifier.urihttp://hdl.handle.net/1885/86318
dc.description.abstractNF-κB transcription factors mediate the effects of pro-inflammatory cytokines such as tumour necrosis factor-α and interleukin-1β. Failure to downregulate NF-κB transcriptional activity results in chronic inflammation and cell death, as observed in A2
dc.publisherMacmillan Publishers Ltd
dc.sourceNature
dc.subjectKeywords: Cells; Degradation; Functions; Signaling; Cell death; Inflammation; Enzymes; cytokine; immunoglobulin enhancer binding protein; interleukin 1beta; lysine; proteasome; protein; protein A20; receptor interacting protein; tumor necrosis factor alpha; tumor n
dc.titleDe-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kB signalling
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume430
dc.date.issued2004
local.identifier.absfor060111 - Signal Transduction
local.identifier.ariespublicationMigratedxPub15153
local.type.statusPublished Version
local.contributor.affiliationWen, S, Louisiana State University
local.contributor.affiliationO'Rourke, Karen, Genentech Inc.
local.contributor.affiliationZhou, Honglin, Genentech Inc.
local.contributor.affiliationEby, Michael, Genentech Inc.
local.contributor.affiliationAravind, L, National Institutes of Health
local.contributor.affiliationSeshagiri, Somasekar, Genentech Inc.
local.contributor.affiliationWu, Ping-Shi, Lehigh University
local.contributor.affiliationWiesmann, Christian, Genentech Inc.
local.contributor.affiliationBaker, Rohan, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBoone, David, University of California
local.contributor.affiliationMa, Averil, University of California
local.contributor.affiliationKoonin, Eugene, National Institutes of Health
local.contributor.affiliationDixit, Vishva, Genentech Inc.
local.description.embargo2037-12-31
local.bibliographicCitation.startpage694
local.bibliographicCitation.lastpage699
local.identifier.doi10.1038/nature02794
dc.date.updated2015-12-12T08:10:18Z
local.identifier.scopusID2-s2.0-3943054838
CollectionsANU Research Publications

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